Fig. 9. Expression of markers of fibrosis and inflammation in New Zealand obese (NZO) mice. (A) Renal mRNA levels of fibrosis markers: collagen type 1, alpha 1 (Col1α1), collagen type 3, alpha 1 (Col3α1), collagen type 4, alpha 1 (Col4α1) and transforming growth factor beta 1 (TGFβ1) in sham-operated group and in UUO-operated group. (B) Renal mRNA levels of inflammation markers: interleukin 1 beta (IL1β), interleukin 6 (IL6), tumor necrosis factor alpha (TNFα), intercellular adhesion molecule 1 (ICAM1), vascular cell adhesion molecule 1 (VCAM1) and monocyte chemotactic protein 1 (MCP1) in sham-operated group and UUO-operated groups. All mRNA expression data are determined in n=5 for sham-operated kidneys, n=9 for UUO-operated kidneys. The relative standard curve method was used for relative quantification. All data are means ± SD., **p<0.01, ***p<0.001, ****p<0.0001 and ****p<0.0001.